The Special Collections and Archives Department is the repository for DePaul University Library's rare books and unique documents. Research strengths include the history of urban renewal in Lincoln Park; women's community organizations against domestic violence; Catholic social justice; Victorian illustrated books; Napoleon; St. Vincent de Paul; and the Congregation of the Mission (Vincentians).

The department also maintains the archives of DePaul University, which include faculty members published books and student theses and dissertations. All collections reflect DePaul's commitment to the academic quality of its curricular programs, the research needs of its faculty, involvement with community organizations, and its Vincentian and Catholic identity.